Comparative Study Of Electrolyte Patterns In Sickle Cell Disease Patients
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Comparative Study Of Electrolyte Patterns In Sickle Cell Disease Patients
ABSTRACT
A comparative study of electrolyte trends in sickle cell disease patients in Owerri was conducted. A total of 60 participants between the ages of 18 and 40 were recruited at random.
30 people had sickle cell disease, while 30 subjects who functioned as controls did not. Serum electrolytes were measured using a colorimetric method, and the manufacturer’s standard operating procedures were meticulously followed.
The data were compared between sickle cell sufferers and controls. Comparative analysis was also conducted based on the patients’ age groupings. Statistical analyses were performed using the student independent t-test and anova.
The study found that sickle cell anaemia patients had a significantly lower (P<0.05) blood sodium concentration (102.93 ± 10.91mEq/L) than control subjects (139.10 ± 5.01mEq/L). The older patients had lower sodium levels.
Potassium content in patients (5.53 ±0.37 mEq/L) was substantially lower than in control subjects (4.17 ± 0.49 mEq/L). Potassium levels were greater among elderly patients. The study found that sickle cell anaemia caused a significant (P<0.05) drop in serum chloride content compared to control participants.
In sickle cell patients, the chloride concentration was 73.77 ± 8.06 mEqL, while in normal people it was 103.07 ± 12.41. Older patients had lower chloride levels. The patient’s bicarbonate concentration (17.57±2.47mEq/L) was substantially lower than the control participants’ (24.17±2.49mEq/L).
Patients aged 27-33 had lower bicarbonate levels (17.82± 1.24 mEq/l), while those aged 18-26 had higher levels (20.43±2.18 mEq/l). In conclusion, electrolyte loss in sickle cell disease patients is most likely caused by dehydration
which accelerates the influx and outflow of sodium and potassium ions, respectively. The regular assessment of sodium and potassium is required in the care of sickle cell patients.
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