Evaluation Of Lipids Profile In Tuberculosis (Tb) Patients On Anti-Tuberculosis Therapy
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Evaluation Of Lipids Profile In Tuberculosis (Tb) Patients On Anti-Tuberculosis Therapy
ABSTRACT
This study was conducted to assess serum lipid levels in tuberculosis (TB) patients receiving antituberculosis medication. A total of 60 people were recruited for this investigation.
Twenty volunteers were tuberculosis patients who were not on therapy, twenty were tuberculosis patients who had been on anti-TB therapy for at least three months, and another twenty appeared to be healthy people who served as the control.
Plasma samples from individuals were analysed using enzymatic colorimetric techniques, and the results were compared statistically using SPSS version 20 for Windows. The obtained results demonstrated that the values of total cholesterol level among tuberculosis subjects not on therapy (150.5+ 17.42) were significantly lower than the control subjects of seemingly healthy individuals (175.1+ 26.76).
participants not on medication had significantly lower triglyceride levels (100.7 + 32.64) than control participants (114.7 + 54.57). Subjects not on medication had significantly lower low density lipoprotein levels (94.33+ 10.03) compared to the control (103.5+ 12.39). Subjects not on medication had lower high density lipoprotein levels (47.27 + 4.068) than control subjects (48.60 + 5.863), which was statistically significant.
The total cholesterol level of tuberculosis patients on medication (171.3 + 23.86) was statistically significantly lower than that of control subjects (175.1 + 26.76). Subjects on medication had significantly lower triglyceride levels (106.1 + 31.17) than the control group (114.7 + 54.57).
patients on medication had no statistically significant decrease in low density lipoprotein levels (100.7+7.324) as compared to control patients (103.5+12.39). There was no statistically significant difference in high density lipoprotein readings between control subjects (48.60 + 5.863) and therapy subjects (51.93 + 3.982).
The total cholesterol levels of participants not on therapy (150.5+ 17.42) were statistically significantly lower than those of subjects on therapy (171.3+ 23.86). The triglyceride levels of participants not on anti-tuberculosis therapy (100.7+ 32.64) were not statistically significantly lower than those of subjects on anti-tuberculosis therapy (106.1+ 31.17).
The low density lipoprotein values of participants not on therapy were found to be statistically non-significantly lower (94.33+10.03) than those of subjects on therapy (100.7+7.324).
There was no statistically significant difference in high density lipoprotein levels between tuberculosis patients who were not on therapy (47.27 + 4.068) and those who were on therapy (48.60 + 5.863).
The findings revealed a high prevalence of hypolipidaemia among tuberculosis patients, particularly those who were not on therapy. Additionally, the study found that therapy altered lipid profile levels. The study’s findings could be utilised to monitor illness severity and treatment progression.
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