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TABLE OF CONTENTS
Title Page
Certification
Dedication
Acknowledgments
Abstract
Table of Contents
List of Tables
List of Figures
CHAPTER ONE: INTRODUCTION
Background of the studyStatement of Research ProblemJustification of the StudyScope of Study
CHAPTER TWO: LITERATURE REVIEW
2.1 Diarrhoea
2.1.1 Types of Diarrhoea
2.1.2 Symptoms of Diarrhoea
2.1.3 Causes of Diarrhoea
2.1.4 Prevention of Diarrhoea
2.1.5 Treatment of Diarrhoea
2.1.6 Health Effects of Diarrhoea
2.2 Castor Oil
2.2.1 Composition of Castor Oil
2.2.2 Mechanism of Diarrhoeal Induction by Castor oil
2.3 Vitamins
2.3.2 Importance of Vitamins
2.3.3 Vitamin C
2.3.4 Role of Vitamin C in the Treatment of Diarrhoea
2.4 Loperamide
2.4.1 Chemical and Physical Properties of Drug
2.4.2 Mechanism of Action of Drug
2.4.3 Medical Uses of Loperamide
2.4.4 Side Effects of Drugs
2.5 Sodium Potassium Adenosine triphosphate (Na+/K+-ATPase)
2.5.1 Functions of Enzyme
2.5.2 Mechanism of Action
2.5.3 Regulation of Enzyme Activity
2.5.4 Role of Na+/K+-ATPase in Diarrhoea
2.6 Alkaline Phosphatase
2.6.1 Structure and properties of enzyme
2.6.2 Physiology of Alkaline Phosphate
2.6.3 Alkaline Phosphatase (ALP) Level Test
2.6.4 Role of Alkaline Phosphatase in Diarrhoea
2.7 Lipid Peroxidation
2.7.1 Mechanism of Lipid Peroxidation
2.7.2 Hazards of Lipid Peroxidation
2.7.3 Lipid Peroxidation Tests
2.7.4 Lipid Peroxidation and Diarrhoea
CHAPTER THREE: MATERIALS AND METHODS
3.1 Materials
3.1.1 Experimental Animals
3.1.2 Apparatus
3.1.3 Chemicals
3.1.4 Source of the Drugs
3.2 Methods
3.2.1 Preparation of Dugs
3.2.2 Induction of Diarrhoea
3.2.3 Experimental design
3.2.4 Sacrifice of the Animals
3.2.5 Collection of Samples
3.2.6 Measurement of body weight
3.3 Estimation of Enzyme activities
3.4 Lipid Peroxidation Test
3.5 Statistical Analysis
Chapter four: results
4.1 Effects of Treatment on Body Weight
4.2 Effects of Treatment on Enzyme Activities
4.2.1 Effects of Treatment on Na+/K+ ATPase activity
4.2.2 Effects of Treatment on Alkaline Phosphatase activity
4.3 Effects of Treatment on Lipid Peroxidation
CHAPTER FIVE: DISCUSSION AND CONCLUSION
5.1 Discussion
5.2 Conclusion
REFERENCES
EFFECT OF A COMBINED TREATMENT OF VITAMIN C AND LOPERAMIDE ON INTESTINAL SODIUM AND POTASSIUM ION ATPASE, ALKALINE PHOSPHATE AND LIPID PEROXIDATION ON CASTOR OIL INDUCED DIARRHOEAL WISTAR RATS
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