Effect Of Crude Of Aloe Barbadensis On Some Hemostatic Parameters Of Fed On Thermoxidized Palm Oil Diets
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Effect Of Crude Of Aloe Barbadensis On Some Hemostatic Parameters Of Fed On Thermoxidized Palm Oil Diets
Chapter one
Introduction and Literature Review
1.0 Introduction.
Aloe barbadensis, sometimes known as aloe Vera, is a succulent plant belonging to the “Liliaceae” family that originated in Africa. The genus goes by a variety of names, including aloe vera, lily of the desert, burn plant, the plant of immortality, first aim plant, wand of heaven, and medical plant.
The word “Alloeh” means “shining bitter substance” in Arabic. The genus contains at least 324 species of herbs, shrubs, and trees (Crosswhite & Crosswhite, 1984). Aloe vera is a perennial plant with 15-30 thick leaves up to 0.5m long and 8-Pcrn across the base.
Leaf margins are marked with saw-like teeth (Grindlay and Reynolds, 1986). Aloe vera plants can tolerate high temperatures and long periods of drought thanks to their ability to retain water in their succulent leaves.
However, freezing temperatures can harm or kill plants. Aloe vera has been used medicinally and non-medically for thousands of years in cultures ranging from ancient Egypt to Greece, Rome, China, India, and Africa (Crosswhite and Crosswhite, 1984; Grindlay and Reynolds, 1986).
Dioscorides, a Greek physician from the first century CE, utilised aloe Vera to treat mouth infections, ulcers, wounds, and purgatives. Egyptians, Assyrians, and Mediterranean peoples employed latex and gel as purgatives. Arabs, Spaniards, ancient Greeks, and Persians used the herb, and African hunters continue to use it to reduce perspiration and body odour.
Egyptians documented the use of aloe vera to cure burns, parasites, and illnesses about 500 B.C. The Egyptians dubbed the plant “the plant of immortality” since it can live and even blossom without soil, and it was used as an offering at pharaohs’ funerals.
It was also employed in the baths of Egyptian rulers Nefertiti and Cleopatra to maintain their skin supple and youthful (Pamplona Roger, 2001). Today, Egyptians still hang an aloe vera plant over the door of their homes to ensure a long and productive life for the occupants.
In India, the herb is used as a stomachic, anthelmintic, emmenagogue, and cathartic. Aloe vera latex was utilised as a laxative in the United States prior to the 1930s (Tonne, 1961; Crosswhite and Crosswhite, 1984; Grindlay and Reynolds, 1986; Evens 1996).
1.2 Goals and objectives of the study
The purpose of this study is to determine the effect of crude aloe barbadensis (aloe vera) on various haemostatic parameters of animals fed thermoxidized palm oil diets. The goal is to see if aloe vera affects haemostatic derangements caused by a diet high in thermoxidized palm oil.
1.3 Justification for study
Aloe vera has been shown to have anti-inflammatory, laxative, antihypertensive, anticancer, and hypoglycemic properties, but little research has been conducted on its effects on haemostasis, particularly in rats fed a diet containing thermoxidized palm oil. This study aims to elucidate its effect on the haemostatic parameters of rats fed thermoxidized palm oil diets.
1.4 Scope of the Study
The study’s scope includes measuring bleeding time, clotting time, prothrombin time, and platelet count in 5 albino wistar rats fed with pellet mixed with thermoxidised palm oil, as well as 5 albino wistar rats fed with the same mixed pellet and 0.1ml/100g body weight of refined aloe vera gel orally administered for four weeks (28 days) and comparing the results with a control group (5 albino wistar rats fed only on normal pellet for the same period).
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