Project Materials

PHYTOCHEMICAL ANALYSIS AND THE ANTI-INFLAMMATORY ACTIVITIES OF DICHLOROMETHANE FRACTION OF METHHANOL EXTRACT OF CRATEVA ADANSONII

ABSTRACT

Inflammation is a complex biological reaction of vascular tissue to adverse stimuli such as pathogens, damaged cells, or irritants (Ryan & Majno, 1983). The urgency created by the increased rate of stroke and atherosclerosis associated with the prolonged use of cyclooxygenase-1 and cyclooxygenase-2 inhibitors has accelerated anti-inflammatory drug research over the last decade, while synthetic pharmaceutical agents have continued to dominate research (Ryan & Majno, 1983). Natural products have received an increasing amount of attention. These are frequently less expensive and more widely available, and they are sometimes thought to be more effective than traditional anti-inflammatory medications. Anti-inflammation was carried out on 12 rats, which were separated into three groups of four each. Groups 1 and 2 functioned as negative and positive controls, respectively. Group 3 got 25mg/kg b.w. of the dichloromethane fraction of methanol extract of Crateva adansonii, which demonstrated significant anti-inflammatory efficacy as compared to the standard difference utilised.

Chapter one

Introduction

Aim and Objectives

Inflammation is one of the body’s inherent protective mechanisms. It is also a necessary response of the body to infection. Too little inflammation, and the body is unable to combat microbial invasions or heal damage. Too much inflammation causes the immune system to attack its own organs, eventually leading to chronic illness (Sears, 2000).

Anti-inflammatory refers to the ability of a drug or treatment to diminish inflammation. Pain, redness, fever, oedema, and loss of function are all clear clinical indicators of inflammation (Pai et al. 2004).

However, if inflammation continues unchecked, it can lead to neurological illness or malignancy (Pai et al. 2004). There are several safe and effective anti-inflammatory medications available, including nonsteroidal anti-inflammatory medicines and corticosteroids.