Effect Of Early Life Exposure To Air Pollution On Development Of Childhood Asthma
Need help with a related project topic or New topic? Send Us Your Topic
DOWNLOAD THE COMPLETE PROJECT MATERIAL
Effect Of Early Life Exposure To Air Pollution On Development Of Childhood Asthma
Early Life Exposure to Air Pollution and the Development of Childhood Asthma. BACKGROUND:
Early environmental exposures are increasingly recognised as important in the development of childhood asthma. Outdoor air pollution is a known asthma trigger, although it is uncertain if exposure affects incident disease.
In a population-based nested case-control study, we looked at how exposure to ambient air pollution in utero and throughout the first year of life affected the chance of later developing asthma.
METHODS:
Using outpatient and hospitalisation records, we examined the incidence of asthma diagnosis in all children born in southwestern British Columbia in 1999 and 2000 (n = 37,401) up to the age of 34. Asthma cases were age and sex matched to five randomly selected controls from the eligible cohort.
We calculated each individual’s exposure to ambient air pollution during the prenatal period and first year of life using high-resolution pollutant surfaces generated from regulatory monitoring data, as well as land use regression models adjusted for temporal variability.
We utilised logistic regression to evaluate the impacts of carbon monoxide, nitric oxide, nitrogen dioxide, and particulate matter.
RESULTS:
3,482 children (9%) were diagnosed with asthma. We found a statistically significant increase in the likelihood of asthma diagnosis with greater early life exposure to CO, NO, NO2, PM10, SO2, and black carbon, as well as proximity to point sources.
Traffic-related pollutants were linked to the highest risks: adjusted odds ratio = 1.08 (95% confidence interval, 1.041.12) for a 10-microg/m3 rise in NO, 1.12 (1.071.17) for a 10-microg/m3 increase in NO2, and 1.10 (1.061.13) for a 100-microg/m3 increase in CO. These findings lend support to the concept that early childhood exposure to air pollution contributes to the development of asthma.
Need help with a related project topic or New topic? Send Us Your Topic